Based on RS, GIS and Apack software, the indices of landscape pattern such as landscape area index, landscape diversity index and landscape fragmentation index were chosen in order to describe changes in the spatial pattern of alpine wetland landscape on the Zoige Plateau during 1966–2000. Results showed that alpine wetland landscape was characteristic of marsh wetlands, which had the biggest patch number and the largest area. The alpine wetland landscape had higher spatial heterogeneity. The largest area appeared in Zoige County with the highest wetland ratio; comparatively, Aba County and Luqu County had much lower wetland ratio. The total area of alpine wetland landscape decreased rapidly during 1966–1986, but it began to increase after 1986. The wetland landscape area shrank by 59857.83 hm² during 1966–2000. The alpine wetland landscape showed the characteristics of concentrated distribution in the past four decades, with higher convergence and dominance indices. The centroid of wetland landscape moved 12.54 km in the northwest direction firstly, 11.33 km in the southeast direction, and then 1.1 km in the north direction.