The change characteristics of regional Normalized Difference Vegetation Index (NDVI) are important indicators of environmental capacity and ecological development. Based on SPOT/VEGETATION NDVI data and ESA CCI-LC Vegetation classification data, using Theil-Sen+ Mann-Kendall, coefficient of variation, Hurst index and correlation analysis method, the spatio-temporal variation characteristics of normalized indices of different vegetation types and the response relationship between climate factors were analyzed in Liaoning Province from 2000 to 2019. The results showed that:(1) the mean value of NDVI decreased gradually from arbor vegetation to steppe vegetation, and different vegetation types had different growth habits in the growing season. (2) All vegetation types showed an increasing trend. Combined with Hurst index and Sen trend, 36.26% of the vegetation in Liaoning Province would be improved, while 61.51% of the vegetation would be degraded. (3) The results of variation coefficient showed that among all vegetation types, arbor vegetation was the most stable, while steppe vegetation was the most unstable. (4) NDVI of all vegetation types in Liaoning Province was significantly positively correlated with precipitation, but relatively low correlated with air temperature. The results can provide a reference for the ecological evaluation and carbon cycle study of Liaoning Province.