To implement the strategy of rural revitalization, industry prosperity is the key. An effective way to revitalize the rural industry is to develop a characteristic economy of selenium-rich agriculture based on the advantage of regional selenium-rich soil resource endowment. Using multidimensional hyper-volume niche theory as the guide, with regional selenium-rich soil resources endowment and selenium-rich agricultural development as the foundation, from three aspects of soil conditions, land use and ecological protection, to clear about the selenium-rich soil resources development and utilization of the dominant factor, geographical factors, limiting factors, discussed to build the selenium-rich soil resources development and utilization of ecological suitability evaluation index system. The method of calculating the comprehensive index of niche suitability for the exploitation and utilization of selenium-rich soil resources was discussed using the relevant model of niche suitability evaluation. Based on the improved zoning of soil utilization, the functional zoning of soil utilization, and the zoning of selenium-rich agricultural production, the suitability zoning of regional selenium-rich soil resources was analyzed. This research can provide scientific and feasible ideas and methods for evaluating the suitability of exploitation and utilization of selenium-rich soil resources. It also produced important guidance with practical significance, which will promote scientific and rational utilization of selenium-rich soil resources in the region and realization of the scientific development of a selenium-rich agricultural industry.