At present, the domestic and overseas academic community has not reached a consensus on the definition of national park tourism sustainability and its evaluation indicators. Some existing indicators that have been applied to foreign national parks have problems like poor operability and high management cost. So they can't be directly applied to the management and evaluation of the Chinese national park tourism sustainability. Therefore, in this paper, the authors established an evaluation indicator system of national park tourism sustainability management from three paths: 1) based on actual demand, the demand for tourism sustainability management evaluation indicators in the area where the national park is located is analyzed; 2) based on international consensus, the applicability of Global Sustainable Tourism Criteria for Destinations is tested; 3) based on practical experience, the management emphases for tourism sustainability of national parks in major nations and regions are summarized. Taking Selin Co-Puruogangri Glacier National Park potential construction area as an example, the national park tourism sustainability evaluation indicator system was established. From the aspects of economy, society, culture and ecological environment, the demand of the national park potential construction area for tourism sustainability evaluation indicators was analyzed. Through applicability judgment, the evaluation indicators with strong applicability of sustainable tourism destination for Selin Co-Puruogangri Glacier National Park potential construction area were identified. Through frequency statistics, the key management indicators of national park tourism sustainability in major nations and regions were selected from the aspects of economy, society, culture, ecological environment and system construction. The evaluation indicator system includes 5 first-level indicators, 15 second-level indicators and 36 third-level indicators. The evaluation indicator system has characteristics as follows: 1) systematic characteristic: the indicator system is clearly-classified, logically-clear, and has a strong integrity; 2) maneuverability characteristic: the indicator system has the availability of data and information in the Selin Co area, and will not significantly increase the management costs of national park management agencies; 3) regional characteristic: relevant indicators can reflect the typical regional characteristics of high altitude, low latitude, and ecological fragility, as well as Tibetan cultural characteristics; 4) representative characteristic: the indicator system not only reflects the international consensus of sustainable tourism destinations, but also absorbs the sustainability management experience of national park tourism in different nations and regions. The application of evaluation indicator system of national park tourism sustainability management should be supported by monitoring and statistical systems. Monitoring of number of tourists, rare and endemic species, water environment quality, vegetation coverage, and traditional building integrity should be further strengthened by Selin Co-Puruogangri Glacier National Park potential construction area. The statistical work on attributes of tourists, satisfaction of tourists, contributions of tourism to local economic and social developments, and the treatment rate of tourism waste should also be further strengthened by the potential construction area.