With the globalization of production and trade, the impact of economic activities on ecological system is no longer a regional issue, but a matter of global importance. The transfer of ecological elements caused by the division of labor in global value chain (GVC) has gradually become a key issue related to the national resource security and social sustainable development. Based on the value disassembly and supplier distribution data of iPhone6, a hybrid multi-region input-output model is applied to the systematical calculation of virtual water use generated by its production. The results show that: (1) generally, 7371 m³ of water resource is needed to produce an iPhone 6, whose production is strongly dependent on the global water supply. The components with largest water use in the manufacturing process are Main PCB, Cover Plate and Else, Display/Touchscreen Module. (2) Regionally, virtual water embodied in iPhone6 mainly roots from 29 countries or regions, while 24 of them are in Asia and Europe. The United States, where Apple Inc. is located, accounts for only 51.66% of total virtual water, while China accounts for 39.05%, being the largest contributor among other economies. (3) During production, the substantial amount of virtual water transfers from the developing countries to the developed countries, such as China-US, China-Japan, Philippines and Malaysia-Singapore, reflecting the role of iPhone6 GVC in global water resources redistribution. (4) In terms of environmental concern, the virtual water intensity of economies and economic sectors involved in iPhone6 GVC is lower than that of the world average, showing better water management awareness and ability. These findings reveal the impact of iPhone6 production on global water budget, and actors in GVC should pay joint efforts to achieve environmentally friendly and sustainable iPhone6 production.