Current Intergovernmental Panel on Climate Change (IPCC) projections indicate that the atmospheric carbon dioxide concentration (\[CO2\]) will increase from current 381 μmol mol-1 to at least 550 μmol mol-1 by 2050, which will have profound impacts on global food production and security. The Free Air CO2 Enrichment (FACE) experiments, conducted in fully open-air field condition without altering microclimatic and biotic variables represent our best simulations of the future high \[CO2\] environment. Oryza sativa L. (rice) is one of the most important crops in the world. However, over the last decade (1998-2007), only two large-scale (12m diameter) replicated rice FACE experiments have been conducted across the world, one commenced in Iwate, Japan in a cool temperate climate, the other in Jiangsu, China in a warm sub-tropical climate. In this review, we mainly focused upon studies of the effects of rising \[CO2\] on rice yield, compared the similarities and differences in yield responses between FACE and different enclosure methodologies, evaluated the interactive effects of CO2 by biotic (varieties, insects, diseases and weeds) and abiotic factors (nutrient and water availability, temperature and ozone), and primarily identified adaptation strategies of rice production to future high-CO2 environments. Based on the current progress, further research orientation in this field was discussed.