In this work, the adsorption of lysozyme（LSZ）on the α-MnO2 and by which factors this process is affected were investigated. The results showed that the system pH value was a most important factor affecting adsorption and desorption of LSZ. In the pH range of 3.8 to 10.8, the adsorption percentage of LSZ on α-MnO2 was increased as pH value raised. The desorption percentage of lysozyme usually increased at low pH condition（pH<7.1）but slightly decreased at high pH condition(pH>7.1). However, the desorption percentage was generally low at all pH values tested, indicating the irreversibility of protein adsorption to the surface of α-MnO2. We also found increasing the ionic strength might increase the LSZ adsorption percentage,but there was no difference on effects of Na+、Ca2+ and Mg2+ on this adsorption. The LSZ adsorption isotherm belonged to the L type, and was fitted well by the Langmuir model. FTIR spectra further approved that LSZ was attached to the surface of mineral, and the spacial structure of attached protein was changed.