Eco-efficiency reflects the double-thinking on economic and ecological issues. It emphasizes to promote economic development with the smallest environmental impacts. Greenhouse gases emission (GHG) has been one of the focuses of global environmental issues, and quantification of GHG emissions of tourist activities is one of the difficulties in tourism environmental impacts study. Making tourism products as study project, and GHG emission of tourist activities as eco-efficiency indicator, calculation model of tourism itinerary products′ eco-efficiency was established in this study. The eco-efficiency of product-series of “8-day tour in Shangri-La”, the typical tourism products in Yunnan China, was calculated and analyzed. The results showed that: (a) There existed great difference between both various departments and different products of tourism. (b) Transportation and catering were the key elements influencing the eco-efficiency of tourism itinerary products. (c) Influences to tourism itinerary products′ eco-efficiency mainly came from economic value and CO2-e emissions. Economic value included expenditures of package-price items and self-help items. CO2-e emissions primarily referred to transportation, tourism product mix and energy types. Study tourism eco-efficiency from the perspective of tourism products would help tourists and tourism practitioners understand eco-efficiency, and improve their ecological consciousness.