The ecosystems on the Qinghai-Tibet Plateau are highly fragile. Climate warming has lengthened the plant growth period on the Qinghai-Tibet Plateau, which may increase the risk of freezing exposure in the early and late growing seasons. Knowledge on the spatiotemporal variations of freezing events during the growing season will contribute to a deeper understanding of the response and adaptation mechanisms of plant growth to climate change on the Qinghai-Tibet Plateau. However, to date, there is still a lack of systematic understanding of the spatial and temporal differentiation of growing-season freezing events and its environmental drivers on the Qinghai-Tibet Plateau. In this study, we defined the climatological growing season based on the daily temperature data of 109 weather stations on the Qinghai-Tibet Plateau from 1951 to 2011. Rstudio was used to analyze the frequency and intensity of growing-season freezing events at each station year by year. The main results were as follow: (1) During 1951-2011, the frequency and intensity of freezing events during the whole and different phases of growing season decreased simultaneously at ca. 65% stations on the Qinghai-Tibet Plateau, but climate stations in the eastern part of the plateau and along the Brahmaputra Valley showed a slight increasing trend. (2) The intra-annual distribution of growing-season freezing events had changed systematically among different decades. The dates of the peak distribution probability of growing-season freezing events from 1951 to 1990 were relatively stable. From 1991 to 2011, however, the dates of the peak probability of early- and late-season freezing events were 11-29 days earlier and 6-29 days later respectively, and such time shifts were particularly evident at sites where the frequency of growing-season freezing events decreased. (3) The long-term trends of the onset of the growing season and the growing-season temperature were the main environmental factors that affected the frequency of growing-season freezing events. When the advance of the onset of the growing season exceeded 4.37d/10a or the increase of growing-season temperature was less than 0.05℃/10a, the frequency of growing-season freezing events would increase. However, the long-term trends of various environmental factors had a minor impact on the changes in the intensity of growing-season freezing events. The results revealed the spatiotemporal differentiation characteristics and its environmental drivers of growing-season freezing events on the Qinghai-Tibet Plateau under climate warming, which can provide key scientific basis for the management and protection of vegetation ecosystems on the Qinghai-Tibet Plateau under climate change.