Species distribution scope changes caused by climate change have posed a serious threat to global biodiversity conservation. Aiming to understand the impact of climate change on the valuable animal giant panda, we took Min Mountains area of the Giant Panda National Park as an example, selected 326 giant panda trace points and 16 environmental variables in 4 categories including climate, topography, biological environment, and human disturbance. Then we used the MaxEnt(maximum entropy, MaxEnt) model and CMIP6 climate model data to explore the main environmental variables affecting the distribution of giant panda, obtained giant panda habitat by simulating the present (2004-2020) and predicting the future (2050s): low compulsion scenario (SSP1-2.6) and high compulsion scenario (SSP5-8.5), analyzed the spatio-temporal variation characteristics and trends of habitat suitability. Results show that: (1) Climatic variables had a great impact on the distribution of giant pandas in the Min Mountains area, and the main influencing variables were the maximum temperature in the warmest month (Bio5), altitude, precipitation in the warmest quarter (Bio18) and distance from the road. (2) The habitat quality was good at the present, but will decline in the future. The area of suitable habitat under the present climate accounted for 67.88% of the total area, the reduction rate of suitable habitat area for giant panda will be 2.03% (SSP1-2.6) and 33.73% (SSP5-8.5) in the future. (3) In the SSP1-2.6 scenario, the main area of suitable habitat loss was located in the eastern part of Min Mountains area, while in the SSP5-8.5 scenario, there was a large amount of habitat loss in the northern and southern parts of the area. In both future climate scenarios, the new suitable habitat were mainly located in the northwestern part of the area. (4) The center of mass of giant panda suitable habitat will move to the west and northwest direction, high latitude and altitude area in the future. (5) Giant panda was mainly active in high and medium suitable habitats. The occurrence frequencies of giant panda in high and medium suitable habitats under the present climate were 67.79% and 24.23%, SSP1-2.6 were 45.09% and 27.61%, SSP5-8.5 were 21.47% and 26.69%, respectively. The study suggests that future attention should be paid to the loss and increase of giant panda habitat under climate change. It is recommended that the Giant Panda National Park should strengthen the monitoring and protection of panda habitats by identifying priority conservation areas, optimizing ecological networks, and adjusting management zones, so as to comprehensively improve the regional climate adaptation ability.