Comprehensively evaluating the ecological health benefits of typical natural resource elements and clarifying the social-economic-natural driving mechanisms is of great significance in guiding the layout of ecological restoration projects, maintaining regional ecological security and achieving sustainable development goals. Nevertheless, there are few case studies on the analysis of spatio-temporal heterogeneity and its driving force for the healthy development of mountains-waters-forests-farmlands -lakes-grasslands (seas). The Guangxi Beibu Gulf Economic Zone includes 6 cities, covering both inland and coastal areas, with rich natural resources such as mountains, rivers and seas, and is positioned as a pioneer zone for comprehensively ecological and environmental restoration. Thus, in order to explore the spatio-temporal heterogeneity of the healthy development of mountains-waters-forests-farmlands-lakes-grasslands (seas) and its driving factors and mechanism, this paper used the normal cloud model, Dagum Gini coefficient, principal component analysis and spatial-temporal geographical weighted regression under the comprehensive evaluation framework to empirically study the Beibu Gulf Economic Zone in Guangxi from 2005 to 2020.The article sets up an evaluation system from three aspects: land use and structure, investment and income, resources and environment, and sets up a driving force system from three aspects: land intensive use, urbanization development and natural environment conditions. The results show that: (1) Except for Beihai City, whose mountains-waters-forests-farmlands-lakes-grasslands (seas) are sub-healthy, all others are healthy. The Gini coefficient of the three inland cities in the economic zone (0.095) is higher than that of the three coastal cities (0.016). The comprehensive level show that there has obviously spatio-temporal non-equilibrium characteristics, with hypervariable density (46.71%) and intra-city gap (44.93%) being the main causes. (2) The driving mechanism affecting the healthy development of the life community is decomposed into two levels: driving factors and driving elements. The driving factors are as follows: urban land utilization rate (0.427)>disposable income of urban and rural residents (0.397)>average annual precipitation (0.377) >investment scale in real estate development (-0.333)>greening coverage of built-up areas (0.261). (3) The driving elements are as follows: land input degree (0.611)>land use degree (0.442)>economic urbanization (-0.393)>natural conditions (0.23), and the spatial non-stationarity is evident in all factors. The study exhibits that the spatial heterogeneity for the healthy development of mountains-waters-forests-farmlands-lakes-grasslands (seas) in the Beibu Gulf Economic Zone is manifested by spatial non-equilibrium of pattern and spatial non-stationarity of factors. Land intensive use, urbanization development and natural environmental conditions are the main driving forces for the healthy development of mountains-waters-forests-farmlands-lakes -grasslands (seas). The mechanism of action among multiple factors reflects that the natural environmental conditions are the basic guarantee, with land intensification being positively promoting and economic urbanization negatively inhibiting. Improving the utilization rate of urban land, increasing the disposable income of urban and rural residents, expanding the green coverage of built-up areas, and controlling the scale of investment in real estate are the key points to improve the level of healthy development of mountains-waters-forests-farmlands-lakes-grasslands (seas).