In order to clarify whether household manure has a promoting effect on vegetation restoration in the desertified land of alpine pastoral areas, the short-term effects between household manure and manure from cattle and sheep were compared on vegetation restoration of sandy land in the Zoige alpine pastoral area, with the effects of the two treatments on vegetation restoration, soil physicochemical properties, soil microbes and soil enzyme activities. The aim is to assess the applicability of household manure for ecological restoration in high-altitude pastoral regions facing desertification. The results showed that both types of fertilizers promoted vegetation growth, with vegetation coverage increasing by over 60% in the short term. Notably, the pioneer herb Avena sativa effectively formed ground cover. Both fertilizers decreased soil pH, increased soil moisture content, and significantly increased the content of carbon, nitrogen and phosphorus in the soil, with the total nitrogen content exceeding 0.8 g/kg. Microbial biomass carbon, nitrogen and phosphorus in the soil also increased under the both fertilizers, accompanied by an increase in soil enzyme activities, particularly a 2-3 times increase in soil urease activity. The short-time function of household manure supplementation in promoting vegetation restoration in alpine pastoral areas was similar to that of traditional organic fertilizer derived from cattle and sheep manure. Consequently, household manure appeared suitable for ecological restoration in the desertified land within alpine pastoral areas. It is recommended to combine the household manure from rural toilet renovation in alpine pastoral areas with traditional cattle and sheep manure. After undergoing standardized and pollution-free treatment, the mixture can be applied to desertification ecological restoration efforts.