Ecosystem restoration is an important measure to maintain and enhance the stability and sustainability of ecosystems. Identifying priority areas for ecological protection and restoration and conducting planned ecological protection and restoration can achieve the goal of suppressing ecological degradation. Taking Zhejiang Province as the research area, the ecosystem service value calculation model, neural network self-organizing mapping (SOM) cluster analysis method, spatial statistics, Spearman non parametric correlation analysis, and other methods are used to identify ecosystem service clusters, analyze the evolution of ecosystem service bundles and changes in human activity intensity, identify priority areas for ecological protection and restoration, explore the trade-off/synergistic relationship between different ecosystem service values, and propose priority area planning strategies for ecological protection and restoration. The results indicate that: (1) From 2000 to 2021, the spatial distribution of ecosystem services in Zhejiang Province gradually tended to be balanced, and the total value of ecosystem services decreased from 727.973 billion yuan to 698.028 billion yuan; (2) From 2000 to 2021, the intensity of human activities in Zhejiang Province significantly increased, showing an increasing trend from west to east and from south to north; (3) From 2000 to 2021, the Moran's I index showed a significant negative correlation between ecosystem services and changes in human activity intensity in Zhejiang Province, indicating that the intensity of human activity and the value of ecological services are spatially interdependent; (4) From 2000 to 2021, 90 counties in Zhejiang Province can be divided into four types of ecosystem service clusters, including urban center clusters, agricultural production clusters, core ecological clusters, and ecological conservation clusters; (5) Based on the clustering results of the bivariate Moran index in 2021, the five types of zoning in the study area will be classified as the primary zoning for ecological protection and restoration, and the dominant ecosystem service cluster in the region will be used as the basis for the secondary zoning for ecological protection and restoration. The priority areas for ecological protection and restoration in Zhejiang Province were divided into four types, namely the ecological prevention and control area accounting for 14.83%, the ecological regulation and construction area accounting for 19.94%, the core ecological protection area accounting for 50.23%, and the ecological comprehensive improvement area accounting for 15.00%. Based on this, the priority strategies for implementing ecological protection and restoration planning in different types of priority zones were proposed.