Building a regional ecological risk assessment framework helps to clearly identify, evaluate, simulate, predict and manage regional ecological risks, and then provide support for the construction of regional ecological security networks and the protection of ecological security patterns. The construction of Xiong'an New Area has caused the area to face huge land use changes, which has a non-negligible impact on the structure and function of the regional ecosystem. Floods and droughts have a significant threat to the ecological system of Xiong'an New Area and its surrounding areas. Taking Xiong'an New Area as an example, a regional comprehensive ecological risk assessment framework including exposure-response relationship, anthropogenic and natural sources is constructed, and the land use change, flood disaster, drought in Xiong'an New Area under the background of urbanization and climate change respectively The regional ecological risks caused by the three types of disaster stresses were evaluated and predicted, and the spatial distribution characteristics and changing trends of the ecological risks were determined. The results show that:(1) From the perspective of time series, due to the impact of natural disasters such as floods and droughts caused by climate change, coupled with land use changes in Xiong'an New Area, the ecological risk of Xiong'an New Area will increase after 2025, but orderly planning and good land allocation will reduce the ecological risk level of the starting area of Xiong'an New Area after 2025; (2) From a spatial perspective, the high-risk areas of Xiong'an New Area are mainly concentrated in the west and south of Baiyangdian Lake, and some areas in the northeast of the new area. Finally, ecological risk prevention and control countermeasures are put forward from the perspectives of land use management, flood and drought disaster prevention:(1) Xiong'an New Area should adhere to reasonable planning and strict management of land use, effectively prevent disorderly use of land, and pay close attention to land use change trends in areas with a high degree of landscape ecological risk and carry out land consolidation when necessary; (2) Xiong'an New Area should focus on the ecological risks caused by conventional floods in the future, strengthen the Xin'an North Embankment, build a safe area for flood disasters in the starting area, and make full use of the wetland to realize the functions of flood storage and drainage; (3) Xiong'an New Area should focus on the prevention and control of drought disaster ecological risks in the northern area, and at the same time try to ensure the water level of Baiyangdian Lake and surrounding rivers to maintain the health of the wetland ecosystem.