Global climate change and urbanization contribute to the increasing deterioration of urban ecological environment. With the growing shortage of urban land resources, the construction of vertical greenery system has played an important role in increasing urban green space, which is of great significance to improve the urban environment. The vertical greenery system has multiple ecological benefits which are greatly affected by various factors in the meantime. Facing a complex relationship network between multiple ecological benefits and influencing factors, it is of urgent need to figure out an optimal solution on coordinating the complex relationship between ecological benefits and influencing factors, so as to maximize the comprehensive ecological benefits of currently vertical greening construction. Therefore, we summarized the mechanisms of different ecological benefits and their key influencing factors based on systematic literature review, and then made a comprehensive analysis of vertical greenery system's multi-benefits and various influencing factors in this paper. Seven main ecological benefits of vertical greenery system were summarized, including alleviating urban heat island, conserving building energy and carbon emission, fixing carbon, purifying air, reducing noise, intercepting rainwater, and maintaining biodiversity. At the same time, several factors, including vegetation characteristics, facilities structure characteristics, meteorological conditions, and spatial pattern, etc., showed significant impacts on the display of ecological benefits. Furthermore, based on the comprehensive analysis of benefits and influencing factors, we put forward two planning views:Firstly, more attention is needed to pay on the coupling relationship between environmental demand and benefit supply, which could effectively provide scientific and reasonable guidance on the layout of regional vertical greenery system construction. Secondly, more attention is needed to pay on the relationship between ecological benefits, and more efforts should be made to trade off between 7 ecological benefits by taking the regional key ecological environmental issues as the orientation, and also recognize the importance degree of their influencing factors. The combined results will be able to provide effective suggestions on the design strategies of vertical greenery system to maximize comprehensive benefits.