The current research progress on wildlife trouble is systematically reviewed in this article, and the hot spots and research difficulties are comprehensively sorted out, including spatio-temporal characteristics, damage assessment and prevention strategies. At the same time, the intense debates of wildlife trouble are pointed out, that is how to coordinate community development and wildlife protection, how to conduct the compensation for animal troubles, whether the local aborigines or wildlifes should be relocated, whether to use biological or genetic control, etc. On this basis, the future research is prospected, such as breaking through the traditional paradigm of human geography, introducing multidisciplinary perspectives, taking into account the different concerns of stakeholders, and paying attention to nature reserves, etc. It is hoped to provide some valuable references for subsequent research.