To explore the influence mechanism and regulation measures of the combined stress of Zn, Cu, and salt for the germination and growth of Suaeda salsa, Suaeda salsa was taken as the research object of this paper. Taking the method of hydroponic experiment, the germination percentage, germination rate and osmotic adjustment substance content of Suaeda salsa seeds under the combined stress of Zn, Cu and salt were determined. The effects of 1.5 mg/L indoleacetic acid (IAA), 100 mg/L gibberellin (GA) and 0.3% potassium nitrate (KNO₃) on the germination and growth of Suaeda salsa under the combined stress of Zn, Cu and salt were studied. The results showed that: (1) the combined stress of Zn, Cu, and high concentration salt could significantly reduce the germination percentage of seeds of Suaeda salsa. The combined stress of Zn, Cu, and salt with the medium and high concentrations could significantly inhibit the germination rate of seeds of Suaeda salsa. The effect of Zn, Cu and salt combined stress on the germination and growth of Suaeda salsa seeds showed the effect of low concentration promotion and high concentration inhibition. There were obviously synergistic effects among the influencing factors. (2)The activity of catalase (CAT), peroxidase (POD) and superoxide dismutase (SOD) in Suaeda salsa seedlings increased first and then decreased with the increase of salt concentration under the combined stress condition of the treatment of Zn, Cu, and salt. The content of malondialdehyde (MDA) in Suaeda salsa seedlings increased by nearly 2.5 times under the combined stress condition of Zn, Cu, and high concentration salt. (3)The 1.5 mg/L IAA solution for 12 h could significantly increase the germination percentage and germination rate of seeds under the combined stress of Zn, Cu, and excess salt, reduce the MDA content and significantly enhance the activity of POD and CAT, thereby reducing the damage of the combined stress to Suaeda salsa. It is suggested that under the combined stress of Zn, Cu and high salt, seeds of Suaeda salsa should be soaked in 1.5 mg/L IAA solution for 12 hours before replanting in coastal degraded wetland to improve the ecological restoration efficiency of Suaeda salsa wetland.