Human activities and landscape pattern are important representations of two major elements in the human-land system. Therefore, analyzing coupling characteristics of human activity intensity and landscape patterns is of great significance to reveal the evolution of regional human-land relationships. In order to fill the hole on the coupling response of human activity intensity and landscape pattern, the mountainous human activity intensity and landscape pattern coupling model was constructed, and the comprehensive dominant-recessive human activity intensity index (CHAI) was proposed. Moreover, we quantitatively evaluated the human activities intensity of Fengjie County in the hinterland of the Three Gorges Reservoir Area (TGRA) from 2000 to 2020, and analyzed spatial coupling patterns between the CHAI and landscape pattern through the bivariate spatial autocorrelation model. The results show that:(1) the CHAI of Fengjie County increased from 11.59% to 12.48% during 2000-2020, and the spatial change indicated the characteristics of closely related to the terrain gradient with overall shrinkage while local enhancement. (2) The spatial coupling between the CHAI and landscape pattern in Fengjie County shows four types:coordination type, antagonism type, gradually coordinated type, and gradually antagonistic type. (3) The important impact factors of the coupling between the CHAI and landscape pattern are distance to the settlement, distance to the county administrative center, elevation, and socio-economic factors become the main factors in the evolution of regional social ecosystem. (4) There are diverse and special coupling response between human activity intensity and landscape pattern in the hinterland of the TGRA. In general, the hinterland of TGRA has achieved win-win situation for the ecological and economy through partial disharmony in exchange for overall coordination. Moreover, the results reveal the uniqueness of China's mountainous landscape pattern in response to human activities in recent years.