It is vital for China to investigate the coupling and coordination relationship between technological innovation and ecological environment to accomplish its high-quality development strategy currently. In order to solve the question mentioned above, this paper first elaborated the mechanism process of the coupling and coordination relationship between technological innovation and the ecological environment. After that, this paper chose the Pearl River Delta region as the study area and we focused on the period from 2007 to 2018, and a comprehensive evaluation indicator system has been constructed to evaluate the situation of technological innovation and ecological environment in the Pearl River Delta region from 2007 to 2018. Subsequently, we quantitatively calculated the coupling coordination level between technological innovation and ecological environment with the help of coupling coordination degree model of physics. What"s more, this paper analyzed and discussed the spatiotemporal evolution characteristics of their coupling coordination development situation in the Pearl River Delta region from 2007 to 2018 as well. Our findings are as follows. Firstly, both the situation of technological innovation and ecological environment shows a gradual upgrade trend in all cities of the Pearl River Delta from 2007 to 2018. More importantly, the coupling degree and the coupling coordination degree between technological innovation and ecological environment also showed the positive characteristics that move from low level state to more advanced state. As for spatial distribution, the coupling coordination degree between technological innovation and ecological environment in the Pearl River Delta region shows a significant spatial pattern which descended from the core region to the periphery, meanwhile, Guangzhou, Shenzhen, Foshan and Dongguan such developed cities are situated in central area. In terms of coupling and coordinated types, although most cities" technological innovative ability hinders the improvement of coupling coordination degree between technological innovation and the ecological environment after 2007, the innovation ability of cities has been continuously captured with the ecological environment which pushed the coupling coordination degree to reach the basic coordination or even advanced level as time goes on. However, the development of Zhaoqing is slow compared with other cities, and it still belongs to the "Basic imbalance-technological innovation hindered type" during the study period. Therefore, under the guidance of regional high-quality development strategy, we concluded several developmental strategies for Pearl River Delta to implement the coordinated and sustainable development of technological innovation and ecological environment, for example, improving ecological innovation by increasing investment in innovation factors, controlling pollutant emissions and reasonably maintaining ecological land.