In order to explore the vegetation response difference to flooding events in the coastal and inland areas, this study used the MODIS satellite remote sensing data from 2000 to 2018 in Southeast Asia and the flood data. Two coastal flood events, two inland flood events and one coastal inland flood event with the largest impact since 2000 were identified by comparing the flood occurrence regions in the Southeast Asia. Using Google Earth Engine as the data processing platform, Sen+Mann-Kendall trend method was used to analyze the variation of Normalized Difference Vegetation Index (NDVI) in the study area from 2000 to 2018. It was found that the NDVI in the five study areas showed an upward trend during the 19 years, with an average growth rate of 0.013/10 a. There was no significant difference in the spatial and temporal evolution pattern between coastal and inland vegetation. Based on the analysis of disaster vegetation damage index, it was found that the vegetation damage index of inland and coastal areas under the influence of flood was 0.29 and -0.25, respectively, while the vegetation damage area accounted for 14.29% and 18.11%, respectively. The vegetation damage degree of inland vegetation was less than that of coastal areas. At the same time, excluding the cultivated land and man-made surface with strong human disturbance, the resistance index of vegetation ecosystem to flood events in coastal study area was 88.15, which is significantly stronger than 28.89 in inland area. Grassland showed the strongest resistance, followed by woodland. However, there was an opposite trend in vegetation resilience. In the study, the impact of human activities has reduced the damage of flood disasters to vegetation in inland areas. Researching the differential responses of the coastal and inland vegetation in Southeast Asia to a single flood event and excluding the cumulative effects of flood events in the inland and coastal areas can provide the targeted suggestions for the coastal and inland vegetation in Southeast Asia to resist flood disasters.