Under the urbanization, exploring the responses of different macrobenthic communities to mangrove community changes is of great significance for assessment of mangrove ecosystems health and restoration of degraded ecosystems. This study was performed in the Fujian Zhangjiang National Mangrove Nature Reserve to uncover the effects of mangrove community turnover on different macrobenthic communities (crabs and mollusks) and detect its correlation with environmental factors. The results showed that the environment of the Zhangjiang Estuary mangrove wetland had a great change, showing 7.19 environmental gradients on the 1.6 km geographic scale. On the environmental gradient of this geographic scale, the mangrove community was composed of 5 mangrove species, with an average turnover rate of 76%; The mollusk community consisted of 12 species of mollusks, gathering in a modular and non-random, with an average turnover rate of 83%, and had a significant nonlinear increase with the mangrove turnover, mainly affected by salinity and turnover of Acanthus ilicifolius; The crab community consisted of 20 species of crabs segregated in a more modular and non-random manner, with an average turnover rate of 89%, and linearly increased with the turnover of the mangrove plant community, mainly affected by pH value of sediments and turnover of Avicennia marina. This study investigated the relationship between macrozoobenthic communities and vegetation and their habitat conditions, which provided basic data for the conservation and restoration of mangroves in the context of urbanization.