The comprehensive benefit evaluation of regional ecological restoration will provide decision-making support for ecosystem management and regional ecological restoration results sorting and provide a theoretical basis for future ecological restoration work. However, most of the studies have not formed a systematic theoretical framework in the evaluation process. The selected indicators in these studies are often relatively one-sided, focusing only on a certain field, which unable to form a comprehensive evaluation and overall cognition of the ecological restoration benefits of the study area. Therefore, this study takes Shaanxi Province as the study area, based on spatial remote sensing data and ecological model simulations, the ecological restoration benefits of the region from 2000 to 2015 were comprehensively evaluated from the aspects of ecosystem structure, quality, and service. The results showed that:(1) in the past 16 years, the land use types in Shaanxi Province presented a trend of increasing in forest land and decreasing in the farmland, which was in line with the characteristics of ecological restoration programs such as returning farmland to forest. At the same time, the construction land in Guanzhong area increased greatly, and the main source of construction land was farmland, indicating that urban construction occupied farmland seriously. However, 87.95% and 72.72% of Shaanxi Province increased in vegetation coverage and total ecosystem services, respectively, which indicated that the effect of ecological restoration was obvious despite the increase in human activity. (2) At the time scale, both the vegetation coverage and ecosystem services in Shaanxi Province showed an increasing trend. And at the spatial scale, the average value of vegetation coverage and ecosystem services in the southern Shaanxi were relatively high, especially in the Qinling Mountains, where the ecological environment is superior. Although the mean value of vegetation coverage and ecosystem services in the Northern Shaanxi was relatively low, both of them showed a significant increasing trend, and there is a great potential for the development of ecological environment in the future. (3) Although different ecological programs basically covered the entire territory of Shaanxi Province, the total ecosystem services in Guanzhong and southern Shaanxi still showed a decreased trend due to the meteorological factors. Therefore, in the future implementation of ecological restoration measures in relevant regions, more attention should be paid to the effects of arid environment on ecological restoration. Appropriate restoration measures should be selected according to local conditions to ensure the effectiveness and sustainability, and maximize the benefits of ecological restoration.