To clarify the interaction and response relationship between industrial structure and water consumption structure in Benxi City, the location entropy, grey correlation degree, coordination degree of industrial structure and water structure and structural deviation coefficient were analyzed. The results are as follows. From 2008 to 2017, the development of primary industry in Benxi was stable, the secondary industry grew slowly after a sharp decline, and the tertiary industry became the pillar industry of Benxi after 2016. The proportion of industries was adjusted from 0.06 ∶ 0.60 ∶ 0.34 in 2008 to 0.06 ∶ 0.44 ∶ 0.50 in 2017. Heavy industry and chemical industry, which used to be dominant in the past, showed a downward trend, and the industrial structure has changed. The average water consumption ratio of the three industries was adjusted from 0.39 ∶ 0.59 ∶ 0.02 in 2008 to 0.41 ∶ 0.51 ∶ 0.07 in 2017 and the total water consumption decreased by more than one fourth. In the industries above designated size, the water consumption of most industries increased with the increase of output value, and the production process should be further transformed; Smelting and Pressing of Ferrous Metals, with the highest output value, can be used as an industry to support the development from the perspective of water resources development and utilization. Ferrous Metals Mining and Dressing, Medical and Pharmaceutical Products, Nonmetal Minerals Products and Smelting and Pressing of Ferrous Metals industries with relatively large production scale gradually developed towards a balanced state of water use structure, and it still needs some time to achieve coordination.