When Rice (Oryza stiva L.) is stressed by heavy metal, its growth and development are obviously hindered. The metabolism of rice grown in areas contaminated with heavy metal will change and its growth will slow down, resulting in a decrease in biomass. Among different heavy metals, cadmium is the most harmful to plant growth and human health. Cadmium in the soil is easily absorbed and accumulated by rice, affecting plant growth, cell division and metabolic activities, and causing its yield and quality to decline. Microorganisms play an important role in the remediation of soil contaminated by heavy metal. In this study, Pseudomonas strain TCd-1 was selected from the rhizosphere soil of cadmium-tolerant rice in the early stage of the research group. The Pseudomonas TCd-1 has a strong tolerance to heavy metal cadmium. In this study, two rice species with different cadmium tolerance, Teyou 671 and Baixiang 139, were used as experimental subjects. To elucidate the mechanism of Pseudomonas TCd-1 reducing the cadmium uptake in rice, the effects of inoculated strains on the cadmium content, root vitality, photosynthesis, antioxidant enzyme activity, and antioxidant content of two rice species with different cadmium tolerance were investigated under the stress of 10 mg/kg cadmium. The results suggest that the cadmium contents in the roots, stems, leaves and brown rice of the Teyou 671 decrease by 30.4%, 39.1%, 40.7%, and 29.2%, respectively, while the cadmium content in the roots, stems, leaves, and brown rice of the Baixiang 139 decrease by 52.2%, 51.7%, 18.4%, and 38.8%, respectively, after inoculation with Pseudomonas TCd-1. The root vitality and photosynthesis of the two rice species are improved, leading to promoting the growth of rice. Superoxide dismutase (SOD) activity in the leaves of Teyou 671 and Baixiang 139 increase by 7.3% and 138.5%, Peroxidase (POD) activity increase by 82.0% and 106.2%, Catalase (CAT) activity increase by 58.8% and 172.7%, the flavonoids content in the leaves of two rice species with different cadmium tolerance increase by 139.4% and 73.6%, the total phenol content increase by 27.2% and 23.1%, the superoxide anion content decrease by 44.2% and 29.0%, and the Malondialdehyde (MDA) content in the leaves of two rice species decrease by 38.5% and 28.9%, respectively, in comparison with the treatment of 10 mg/kg cadmium. In conclusion, for two rice species with different cadmium tolerance, after inoculation of Pseudomonas TCd-1 can increase the antioxidant capacity of Teyou 671 and Baixiang 139 with different cadmium tolerance, reduce the oxidative stress, and promote the growth of two rice species with different cadmium tolerance.