Due to the rapid development of social economy, urbanization, and forest industries, the ecosystem service was standing the most withering fire in the south Jiangxi, a typically hilly area in China. To finding the ways on promoting the ecosystem service of hilly area, the multiple effect of landscape pattern on ecosystem service should be investigated. In this paper, we proposed a multiple analysis system to find out the drivers (main landscape types and landscape pattern indexes) of ecosystem service value. All the data was from 2000-2018 statistical yearbook and satellite remote sensing. Landscape pattern indexes was analyzed by Fragstats 4.2 spatial tool, and the multiple relationship of the landscape pattern index and ecosystem service was analyzed by SPSS statistical software. The results showed: 1) Forest land was the dominant landscape type in the southern Jiangxi Province, but landscape type significant affected by human disturbance from 2000 to 2018, leading to an obvious increase of construction land. Fragmentation, heterogeneity, type complexity, and patch separation were all increased, and the dominant patch types in the landscape formed a good connectivity. 2) The value of ecosystem services decreased from 2560.97 billion yuan in 2000 to 2523.54 billion yuan from 2000 to 2018. The forest and construction land ecosystem service has continuous decreased by years, and the forest ecosystem service value contributed the most as a rate of 83.13% (from 2000 to 2010) and 110.75% (from 2010 to 2018). The value of all ecosystem services decreased, only food production performed a unimodal curve and had a peak value in 2010. 3)According to the analysis of the relationship between the landscape pattern index and the ecosystem services, the improvement of ecosystem service value was associated with an increase of the contagion index and reduce of the Shannon's diversity index. However, as the landscape pattern varied among different regions, the relationship of landscape pattern index and ecosystem service value also changed. This paper analyzed the temporal and spatial changes of land use and landscape pattern, investigated the multiple relationship of landscape pattern and ecosystem service under rapid urbanization. We ascertained the main drivers' traits of land use type and landscape indices to represent for changes in ecosystem service. Human interference due to the rapid urbanization gives risk to the degradation of ecosystem service, these risk claims us to do optimize adjustment of the landscape pattern of regions and increase the ability of ecosystem services.