By using the meteorological data of the national meteorological observation stations of six cities (counties) and sea level data of mangrove biome in Beibu Gulf of Guangxi from 1961 to 2019, the basic climatic factors, extreme weather and climate events, sea level change trends and their impacts on mangroves in the past 60 years were analyzed, and the possible impacts of future climate change on regional mangrove plants were analyzed. The results indicate that, the annual average temperature and the annual average minimum temperature in the Beibu Gulf mangrove ecosystem increased. The number of high temperature days increased, the variation trend of the number of low temperature days and annual precipitation were not obvious. The longest continuous days without precipitation in most cities (counties) have no obvious change trend, and the number of annual frost days decreased. The number of tropical cyclone influence decreased but the average intensity increased slightly.The windy days decreased and sea levels are slowly rising. According to the RegCM4 regional climate model, under the RCP4.5 scenario, compared with the reference period (1986-2005), the averagely annual temperature in this ecological area will rise by 0.9-1.4℃, the annual mean maximum temperature and annual mean minimum temperature will both increase, the number of high temperature days will increase and low temperature days will decrease. The annual precipitation will increase by 1% to 2%, the longest continuous number of days without precipitation will increases,and the frost days will decrease in the next 40 years (2021-2060). It is estimated that in the next 30 years, the sea level along the coast of Guangxi will rise by 40-160 mm compared with 2019. The increase of annually mean temperature and extreme temperature, the decrease of cold days and frost days in winter will be both beneficial to the northward expansion of tropical mangrove plants. The increase of evaporation caused by the high temperature in summer, the increase of the longest consecutive days without precipitation in summer and autumn may aggravate the diseases and insect pests in mangroves. The multiple effects of extreme weather and climate events, sea level rise and anthropogenic influences will have a significant impact on the mangrove distribution pattern and the increased risk of ecological degradation.