Mountain area is an important natural resource supplier and ecosystem service provider. Understanding the heterogeneous influence of ecosystem services on human wellbeing is the premise for scientific ecosystem management, which is conducive to the sustainable development of human-land system in mountains. Taking the West Sichuan Mountain Areas in the eastern edge of Qinghai Tibet Plateau as case research object, as the important ecological barriers of upper Yangtze and Yellow River, where is the most vulnerable and poverty concentrated zone in the west. By utilizing the evaluation method for ecosystem service value (ESV) based on per unit area and the framework of human development index (HDI), the ESV model and HDI model were established on the basis of the land use data and social economic data in 2000, 2005, 2010 and 2015. Additionally, geographic weighted regression model (GWR) was applied to diagnose the spatial driving characteristics and dynamic changes of ecosystem services on human wellbeing. The dominant ecosystem service factors were emphatically discussed. The results indicated that:(1) human wellbeing in the West Sichuan Mountain Areas showed homogeneous agglomeration but gradually weakened over time, with "high-high" and "low-low" group concentrated in the south and north, respectively. (2) Regression coefficients indicated that the higher ecosystem service could result in the lower wellbeing on the whole, however the adverse effect tended to slow down. (3) Apparently, influence of ecosystem service factors on human wellbeing varied in local area. The negative effect was obvious measured in the west, while the positive effect was significantly estimated in Aba Prefecture and the northeast of Liangshan Prefecture. The sensitivity decreased from southeast to northwest. The negative influence is stronger than that of positive, the spatial difference of coefficient decreased with time. (4) Supply service and cultural service were found to be the key ecological factors affected wellbeing, the most sensitive area varied in the northeast and west over time. A win-win situation of economic and ecological system should be guided by new development concept. Constructing ecological civilization, establishing ecological zones, and improving the system of paid use of resources and ecological compensation are the main ways to promote ecological resource value creation.