Modeling and scenario analysis are the core contents of land use change research. Facing the increasingly severely ecological environment and food security problems in the process of urbanization, it is of great significance for scientific planning and policy making to carry out land use simulation research under different constraints. In 2018, with the implementation of the pilot program of "ecological restoration and urban repair" in Yangzhou city, urban construction has become another important direction of ecological governance. By the end of 2018, Yangzhou City had completed high-standard basic farmland, accounting for 73.9% of the city's farmland, ranking first in northern Jiangsu Province and third in the province. At present, the provincial eco-circular agriculture pilot village project starts to be constructed, and it is more necessary to speed up the ecological transformation of Yangzhou City agriculture in order to ensure the quantity. In this context, it is particularly important to understand the future change trend of land use pattern under different ecological protection requirements. This paper takes Yangzhou City, a national ecological demonstration city, as an example, to construct a CLUE-S model of the coupled landscape ecological security pattern, so as to predict and simulate the land structure and layout under different scenarios in the planning target year (2030). The results showed that:(1) the proportions of ecological land in the study area under low, medium and high safety levels were 20.68%, 36.50% and 48.81%, respectively. (2) Under the current development scenario, the urban and industrial and mineral land increased significantly, the arable land and garden land were sharply reduced, and the distribution was more fragmented. (3) Under the scenario of cultivated land protection, the cultivated land tended to be contiguous and concentrated, and the expansion of urban, industrial, mining land and transportation land on cultivated land and ecological land decreased. (4) Under the scenario of ecological conservation, the garden land area increased slightly, the expansion rate of urban and industrial land slowed down, food security and ecological security were basically realized. From the comparison of the three scenarios, it can be shown that in the "ecological conversation" scenario of this research, the prohibition of high ecological security areas can not only realize the "dual security" of ecology and food, but also appropriately guide the economical and intensive development of construction land and achieve high-quality development of social economy. In China, the government vigorously develops ecological civilization construction, attaches importance to ecological protection and cultivated land protection, not only because ecological protection and cultivated land protection is the bottom line of social and economic development, but also because reasonable and orderly ecological protection and cultivated land protection can promote the more efficient development of social and economic.