The construction of the Qinghai-Tibet Plateau National Park Cluster (QTPNPC) is an important model for promoting the sustainable development of the Qinghai-Tibet Plateau. Analyzing the regional function and building an orderly spatial organization pattern are key guarantees to promote sustainable development. This study proposes the QTPNPC construction plan based on scientific investigation of the Qinghai-Tibet Plateau and provides an in-depth study on regional function and structure, which is necessary to construct a new group of QTPNPC with a wholesome and integral relationship among ecological conservation, life security, and tourist service functions. Understanding the spatial heterogeneity, time variability, and diverse compounds of the national park cluster is necessary. In terms of the hierarchical structure, it can be divided into 2 transnational national parks, 8 flagship national parks and 11 general national parks. In the future, it can be integrated into other nature protected area in the Qinghai-Tibet Plateau region to form a highly integrated park utilization system. Four primary and mutually dependent characteristics are group-level monomer optimization; national park function, orientation, and organic organization; type, hierarchical, and spatial structures; and integration through domains, lines, and points on three levels. The spatial organization mode is created to allow the QTPNPC to form functional organisms that are closely connected, to steadily develop and evolve in an orderly manner. In construction we need to develop advantage of monomer national park, establish an effective connection among the resource environmental bearing capacity and the national spatial development suitability evaluation, on the basis of comprehensive consideration of ecological importance and vulnerability, the ecosystem services value, according to the actual situation of different national park, thus forms the different characteristic paths. In accordance with the overall goal of the construction of the QTPNPC, we need to explore institutional innovation schemes, legislative systems and construction regulations for national parks, promote the realization of regional functions from the aspects of community development mechanism, franchise operation mechanism, recreation service mechanism and ecosystem product value-added system, and constantly improve the spatial governance system of natural protected areas on the Qinghai-Tibet Plateau, and to promote the construction of an ecological security barrier on the Qinghai-Tibet Plateau and the green development of the region.