Guangdong-Hongkong-Macau Greater Bay area has plenty of heat and precipitation, holding dense river network, tortuous coastline and numerous fjords. The complex natural conditions breed rich wetland resources and constitute an important defense line of regional ecological security barrier. With the rapid development of economy and urbanization in the last four decades, the shrinkage and deterioration of wetland resources are evident. Focusing on the nationally strategic demands, a literature review from the follow aspects are addressed: development of wetland remote sensing monitoring and assessment, problems and challenges of current research, and the future perspectives of remote sensing monitoring and assessment.And then, key scientific questions and technical bottlenecks of wetland protection and utilization are clarified. Moreover, the importance of wetland resource in the construction of ecological sate guarantee system is stated. Based on the challenges the wetland remote sensing monitoring and evaluation confronting, the establishment and implementation of the integrated "sky-air-ground" wetland remote sensing monitoring technology scheme system is in urgent need. Furthermore, several research and application directions of wetland normalization monitoring and asset evaluation in "Guangdong-Hong Kong-Macao Greater Bay Area" are prospected, 1) constructing wetland classification system applied to various natural environment characteristics; 2) upgrading and integrating existed wetland monitoring and evaluation technology, while maximizing the technical advantages of the integrated "sky-air-ground" monitoring platform; 3. combining regional monitoring with key component investigation; 4. expanding research from parameter investigation and monitoring to dynamic resource monitoring and evolution mechanism analysis; 5. developing wetland regionalization and comprehensive management oriented to land and marine coordination; 6. promoting multi-disciplinary, cross-regional and trans-departmental cooperation.