Quantitative analysis of the relationship between the water environmental factors and zooplankton community nearshore of the coastal wetland is of great significance for assessing the sea water quality. Based on the investigation and sampling of the seawater and zooplankton nearshore of Yalu River Wetland National Nature Reserve in December 2019, the influence of environmental factors on zooplankton community structure was analyzed using Redundancy Analysis (RDA) and the Structural Equation Modeling (SEM). A total of 14 species of zooplankton and 5 groups of planktonic larvae were identified, of which the number of copepods was the highest with proportion of 52.63%. None significant difference of zooplankton community was detected among different subareas of the nature reserve. The diversity index, evenness index and richness index of zooplankton community in the study area were 1.34, 0.51, 0.59, respectively. Simulation result of the SEM showed that richness index of the zooplankton community was directly affected by the eutrophication status of the sea water with a coefficient of -0.26 (P=0.01), and was indirectly affected by the heavy metal pollution status with a coefficient of -0.2. This study provides useful insight for the relationship between sea water environmental factors and the zooplankton community, and provides basis for the scientific management of the offshore marine ecosystem of coastal wetland.