The analysis of the relationship between the tree ring width chronology of Larix sibirica and climatic factors in central Altay Mountain, Xinjiang indicates that the mean minimum temperature from June to July is the main climatic factors for the radial growth of trees (r=0.649, P<0.001). Mean minimum temperature equation from June to July in the past 220 years in central Altay Mountain was constructed using the linear regression method, and the interpretation of the variance of the reconstructed equation was 41.1%. The leave-one-out method was used to test the stability of the reconstruction equation, and various test parameters proved that the reconstruction equation was stable and reliable. Inter-annual changes in the reconstructed mean minimum temperature indicated that there are four warm periods (1906-1919, 1922-1935, 1945-1960, and 1997-2017) and four cold periods (1816-1831, 1840-1867, 1869-1886, and 1888-1905) in the study area. These are consistent with the cold and warm stages of the reconstruction sequence of the mean temperature in the adjacent area. The reconstructed sequence with change periods of about 2a, 2.4a, 2.8-3a, 11a, and 20-22a based on the multi-taper analysis indicates that climate change is mainly driven by the global sea surface temperature (SST), sunspots and ENSO (El Niño-Southern Oscillation) in the study area. The reconstructed mean minimum temperature provides a basis for systematically mastering regularity and scientifically predicting future tendency of climate change in the Altay Mountain.