Heavy metals are mainly distributed in rocks and soils in nature, and transfer to other environments through biogeochemical cycles. The continuous development of the traditional and modern human activities not only increases the total amount of heavy metals entering environment, but also changes the migration rate and direction, form and biological toxicity, thus increasing the risk of human health. In order to establish the efficient and feasible remediation of heavy metal pollution, the new process and characteristics of biogeochemical cycle under human disturbances should be fully understood. Therefore, this paper summarized the impacts of human disturbances and a series of environmental changes on the biogeochemical cycle of several key heavy metal elements, and the conclusion was that human disturbances increased the release of the heavy metals and accelerated their migration rates in the water. So the remediation should focus on the restoration and supervision of special areas, such as metal mines and electronic waste dumps, and a variety of remediation methods might be used to prevent the rapid migration of heavy metals in the water, which provide the basis for the research of heavy metal pollution remediation methods.