Miscanthus nudipes is the species which is highly adaptable to extremely cold and drought environments, and has the potential of being domesticated to the species with highly ecological adaptability. Based on the current distribution of the M. nudipes, using the Maxent model to analyze the potential geographical distributions of the M. nudipes in the Last Interglacial Period, the Last Glacial Maximum Period, the Modern Period and in the future (in the year of 2070), respectively. Meanwhile, based on the different species distribution models, this study quantitatively analyzed the changes of suitable habitat areas of the M. nudipes under different climate conditions. The results show that 1) The temperature seasonality plays a core role, which affects the geographical distributions of the M. nudipes. Additionally, the temperature seasonality is 440-645, the lowest temperature of the coldest month is -8.5-0℃, the temperature annual range is 22-30℃, the precipitation in May is 70-115 mm, the altitude range is 1630-3750 m, and the solar radiation in June is less than 15,800 kJ m^-2 d^-1,which provide the best factors for the growth of the M. nudipes; 2)The total areas of the best suitable habitat of the species of M. nudipes is 632,184.45 km², which include Sichuan, Yunnan, Guizhou, Shanxi, Gansu, Hubei, Henan, Chongqing and Tibet Autonomous Region in China. Moreover, the distribution center is the central Sichuan, the northern Yunnan, and the eastern Xizang, respectively; 3) there will be a significant decrease of suitable habitat area from 632,184.45 to 546,745.02 km² during the period from the Last Interglacial period to the year of 2070, which will reduce 94,867.23 km²; 4) From the Last Interglacial period to the Last Glacial Maximum period, the distribution center moved forward to the southeast of China, and from the Last Glacial Maximum period to the future, the distribution center will tend to keep stable. In general, there will be a tendency of the distribution center of M. nudipes moving to the Last Glacial Maximum period distribution center in the future. In summary, the conclusion of this study provided a theoretical method and evidence on the analysis of the origin and genetical evolution of the M. nudipes in the following studies.