The grey water footprint is the amount of freshwater required to assimilate the load of water pollutants in order to meet ambient water quality standards and it is an effective method to evaluate the degree of water pollution and the quality of water. By accounting and analyzing of grey water footprint, it will contribute to improve the water environment and promote sustainable water ecology in Fujian province. We accounted the grey water footprint of Fujian province and 9 local cities from 2001 to 2017 by reference to the grey water footprint accounting method proposed by Hoekstra et al, analyzed the spatio-temporal variations, and applied the Logarithmic Mean Divisia Index Method (LMDI) to investigate the contributions of five driving factors. The results showed as follows. a) The total nitrogen (TN) was considered as the major pollutant of total grey water footprint of Fujian province. Non-point pollution was the major resource of grey water footprint but its proportion have decreased from 68.25% to 63.35%. b) The total grey water footprint decreased by 9.58%, and there was a downtrend of all other indicators. The total grey water footprint and the remaining grey water footprint amount was more in the southeast than that in the northwest, while the west amount was more than that in the east for the per capita grey water footprint and grey water footprint intensity. c) Among the driving factors of Fujian's grey water footprint, the economic factor was dominantly positive, making a contribution of 293.296 billion m³, while the technical factor was the most negative one, making -263.031 billion m³ contribution. Therefore, we suggest that:a) launching a project to prevent and control non-point pollution; b) Speeding up the enhancement of urban sewage treatment technique; c) Optimizing the industrial structure and improving the efficiency of grey water footprint; d) Implying a mechanism for ecological compensation, fully mobilizing the initiative of all quarters to protect water environment; and e) Strengthening the supervision of environment and taking efforts to achieve the integration of technological advance and economic rationality.