Evaluating the responses of soil respiration and its components to warming and land use are crucial for predicting terrestrial ecosystem carbon cycling in the context of global change. Thus, a manipulative field experiment with warming and clipping was conducted in an alpine meadow, Qinghai-Tibetan Plateau to examine how soil respiration and its components in responses to warming and clipping in the growing season (May to September), and their relationships with soil temperature and soil moisture. Results showed that: (1) warming significantly increased soil respiration (31.65%) and heterotrophic respiration (27.12%) while did not affect soil autotrophic respiration. The clipping had no effect on soil respiration and soil autotrophic respiration, but significantly increased heterotrophic respiration by 32.54%; (2) the interaction effects of warming and clipping were insignificant for soil respiration and heterotrophic respiration while were significant for soil autotrophic respiration, and the seasonal dynamics of soil respiration and heterotrophic respiration were significant; (3) soil respiration and its components showed a significant exponential relationship with soil temperature and a positive linear relationship with soil moisture under warming and clipping treatments. Our study suggests positive feedback between soil carbon emissions and global changes such as warming and clipping in an alpine meadow on the eastern Qinghai-Tibetan Plateau.