As a crucial link in the construction of South-Asia channel, the China-Nepal corridor has characteristics of fragile ecological environment and strong dependence on ecological resources. The construction of the China-Nepal corridor would occupy ecological space, which increases the carrying pressure of ecosystem on agricultural and animal husbandry production. Therefore, study of ecological carrying capacity in the China-Nepal corridor has important practical value and guiding significance for the ecological protection of the Qinghai-Tibet Plateau and the construction of South-Asia channel. Based on the balance between ecological supply and consumption, this paper evaluates the ecological carrying capacity of the China-Nepal corridor through calculating Net Primary Production (NPP) consumed by agricultural and animal husbandry production. The results show that (1) the ecological carrying capacity of the China-Nepal corridor is in a state of abundant and 7 counties are in critical overload or balanced surplus state in 2015. On the whole, there is still large ecological space to support the construction of the China-Nepal corridor, but the construction may bring overload risk to some counties. (2) The supply of ecosystem in the China-Nepal corridor is in a stable fluctuation state, and the ecological consumption of animal husbandry plays a leading role in the ecological consumption (accounting for more than 80%). Due to the implementation of the grass-livestock balance policy since 2005, the ecological consumption intensity of the China-Nepal corridor and its 24 counties have declined dramatically, which means that the ecological pressure of agricultural and animal husbandry production is reduced, and the ecological carrying state is developing to a better level. However, the ecological consumption is increasing driven by the growing demand for agricultural and animal husbandry products in local and surrounding areas in seven counties located in the main grain-producing areas, port areas and urbanization radiation areas. (3) If the goal of ecological protection is to protect 50% of the ecological resources advocated by the Convention on Biological Diversity, the ecological consumption of agricultural and animal husbandry production mode in the corridor would exceed its available supply. The regional sustainable development needs to pay attention to how to promote the adjustment of local industrial structure through the construction of the China-Nepal corridor in order to alleviate the pressure of agricultural and animal husbandry production on the ecosystem.