Several programs for National Park pilot areas and institutional reform have been launched since the Third Plenary Session of the 18th Central Committee of the Communist Party of China, and the establishment of the National Park is proceeding steadily. Focused on institution setting, power allocation and operation mechanism, this paper gave some thoughts on the administrative mechanism of nature reserve network dominated by National Park. Foundation of the National Forestry and Grassland Administration enabled the National Park had a uniform administrative institution; the previous responsibilities of multi-institutions had been integrated; and the establishment of National Park network has been promoted greatly due to the transfer of power to the central government and the improvement of regulatory mechanism. Based on advanced experience on establishment of National park. We concluded that the construction of grass-roots institution should be paid more attention to, the regulatory mechanism should be strengthened and the laws should be perfected. We proposed prospects of ecological compensation and varied management modes.