Conflicts between human and bears have become a universal problem in Asia, Europe, and the Americas. Science-based solutions for mitigating the conflicts can contribute to establishment of mechanisms promoting human-bear coexistence. There are seven Ursidae species involved in human-bear conflicts. These include the brown bear (Ursus arctos), Asiatic black bear (U. thibetanus), American black bear (U. americanus), Polar bear (U. maritimus), Sun bear (Helarctos malayanus), Sloth bear (Melursus ursinus), and Spectacled bear (Tremarctos ornatus). Damage types cover attacking human, preying on livestock, house break-ins, damaging crop, raiding beehive, and garbage raiding. Human-bear conflicts result from human encroachment, increase of the bear population, the habitat degradation, seasonal food shortages, accessibility of anthropogenic food sources, and decreasing public tolerance towards the Ursidae species. Present solutions to mitigate human-bear conflicts include the physical, biological, chemical, and policy-oriented measures. However, these tactics are only considered from the technical angle, and fail to take driving factors of human-bear conflicts and local realities into consideration. The Tibetan brown bear (U. arctos pruinosus) is a rare subspecies of brown bear living at high altitude in close proximity to humans in central Asia. In Sanjiangyuan National Park in China, human-bear conflict with the species is of concern. To help shape effective conservation goals for resolving human-bear conflicts in the area, we proposed that:(1) formulation of mitigation measures should be tailored to region, taking into account local realities such as geography, laws and regulations, culture and religious practices; (2) mitigation measures should consistently be updated and improved to address the varying types of damage; (3) research on the relationship between anthropogenic development and the Ursidae survival should be continued. Specifically, the relationship between lifestyle practices and animal behavior should be explored; and (4) research on the ecology of the Tibetan brown bear should be strengthened to identify the driving factors of human-bear conflict in terms of habitat quality, population dynamics, natural food sources, and ecosystem integrity. Mitigation measures should be formulated at a fundamental level with regular assessment of efficacy to promote peaceful human-bear coexistence in Sanjiangyuan National Park.