Forest ecological security plays an important role in maintaining biodiversity, promoting sustainable economic development, and ensuring human survival.In this study, we mainly discussed the influence factors of forest ecological security and the spatio-temporal changes of forest ecological security index, to provide a theoretical reference for improving forest ecological security in Zhejiang Province. Based on the DPSIR(Driving porce-Pressure-State-Impact-Responses)model, the expert method and entropy weight method were used to determine the forest ecological security index of Zhejiang Province. From the perspective of county and district, we calculated and analyzed the forest ecological security index from 2000 to 2015, and observed the spatial change of forest ecological security through the spatial distribution map of forest ecological security index. The results indicates that (1) the response index have the greatest weight, the government policy has a significant effect, and the financial support effect is obvious. (2) The forest ecological security index is relatively safe in Zhejiang Province.The forest ecological security index is between 0.4 and 0.5, showing a volatility upward trend. (3) The state index has the most obvious impact on the calculation of forest ecological security index, followed by the pressure index, impact index, driving force index, and response index.The reduction of natural forest area is the main reason for the decline in the state index.The response index is affected by the interaction of other indexes, and the upward trend is obvious.The economic development has inhibited the improvement of the forest ecological security environment and the improvement of the index to a certain extent in Zhejiang Province. (4) The forest ecological security areas in Zhejiang Province are unevenly distributed. The forest ecological security index in the southwestern region is higher than that in the northeastern region. The county-level index is significantly different, which is affected by both the natural environment and economic development. We provide the suggestions based on the above results: Zhejiang Province should increase policy support and increase investment in forestry ecological construction; accelerate industrial transformation, implement circular economy, and extend enterprise industrial chain; strengthen the construction of forest reserves and formulate relevant regulations to regulate people's behavior.