Landscape multifunctionality refers to the characteristic of landscapes in which they provide multiple different functions, which interact with each other, at the same time. Good landscape multifunctionality can effectively improve regional human well-being, making landscape multifunctionality a typical topic of human-land coupling research. However, vague concepts, rough measurement methods, and a lack of practical application are major obstacles to the further development of landscape multifunctionality research. This study clarified the concepts and the logical relationships among ecosystem function, ecosystem service, land function, landscape service, and landscape sustainability. International studies in recent years classified as agricultural landscape multifunctionality, urban landscape multifunctionality, and other and others featuring regional landscape multifunctionality have been reviewed. The cascade research chain of "pattern, process, service, sustainability" has gradually emerged. Four frontier issues were set in this study, comprising the following: optimizing the indicators and methods of landscape function evaluation based on the principle of supply and demand; correctly understanding the relationship between the dominance and diversity of landscape function; exploring a multi-objective collaborative approach to achieve sustainable development goals; and providing theoretical, methodological, and practical guidance for the optimization of national territory development.