Land-use is the most basic manifestation of human activities. It is essential to explore the response relationship between Karst Rocky Desertification (KRD) and land-use change for the control of KRD and regional sustainable development. Based on LANDSAT and KRD data from 2005 and 2015 in Daozhen County of Guizhou Province, the land-use in Daozhen County was classified into 8 types by ENVI5.3. The spatial and temporal evolution of land use and landscape pattern of KRD in Daozhen County were analyzed using landscape pattern spatial analysis and 3S technology. The results showed that:(1) During 2005-2015, the area of construction land and shrubbery land increased; most shrubbery land was transformed from paddy fields and dry land, and the area increased by 7.51%. Construction land increased by 1.30%. (2) Over the 10 study years, the metastasis between the rocky desertification grades in the study area exhibited light, medium, and severe conversion into potential rocky desertification. The plaque transfer areas were 11.26 km², 38.79 km², and 2.71 km², respectively, indicating a rocky desertification landscape in the study area. The land has been restored, and the area of low-grade rocky desertification plaques has increased, which reduced the superiority of the original high-grade rocky desertification patches; (3) Landscape patterns of land-use and KRD in Daozhen County decreased by 0.6434 and 2.4309 in 2005 and 2015. The evenness index decreased by 0.0552 and 0.5436, the fractal dimension index increased by 0.0061 and 0.0801, the contagion index increased by 0.1751, 25.5396, and the aggregation index increased by 1.8688 and 2.9112, respectively, and the landscape shape index decreased by 0.9812 and 4.536, respectively. The change in the landscape pattern index of land use corresponded to the change in the landscape pattern of KRD. With change of land-use patterns, the contagion index increased by 0.1751, 25.5396, and 2.9112, respectively. The KRD changed accordingly. This study will help to improve people's understanding of KRD and land-use landscape patterns. Based on the landscape ecology background, the effect of KRD control was evaluated, which will provide a reference for future research regarding KRD control.