Based on the MODIS NDVI data set for 2000-2016, we studied the spatial anisotropy of vegetation coverage change depending on north-south slopes, elevation, slope, and slope aspect by trend analysis, and the coefficient was corrected by topography. The results showed that during the past 17 years, the Qinling Mountains have had high vegetation coverage, and it will continue to increase. The vegetation coverage and its variation trend varied with topography. (1) The increasing trend in vegetation coverage was higher in the south slope than that in the north slope. The vegetation coverage in the south slope was dominated by an upward trend, whereas that in the north slope was mainly stable. (2) There was a difference in variation in vegetation coverage at different elevations. The low-elevation area exhibited a decreasing trend, whereas the mid-elevation areas showed an obvious increasing trend. The vegetation coverage was relatively stable in the north slope with an altitude of >2000 m, whereas an obvious decreasing trend was observed between 2500 and 3100 m in the south slope. (3) With the increase in slope, the trend in vegetation coverage change shifted from decreasing to increasing, and turned to stable in the steep slopes. The vegetation coverage change in the north and south slopes did not differ considerably. (4) The vegetation coverage change showed an obvious difference between the north and south slopes on different slope aspects. As the slope aspect shifted from shady to sunny, the change in vegetation coverage was obvious in the north slope, whereas that in the southern slope was not obvious. The distribution of decreased vegetation coverage area exhibited opposite trends in the north and south slopes, which are on the shady and sunny slopes, respectively.