Spatial heterogeneity in fish feeding ecology is the basis for understanding energy flow and material circulation, and for constructing food webs in marine ecosystems. In this study, based on the survey data collected by bottom trawls in Haizhou Bay during the autumn of 2011 and 2013-2016, combined with the spatial distribution pattern and analysis of stomach contents of Chelidonichthys spinosus, the feeding hotspots and spatial heterogeneity in feeding habits of C. spinosus were studied. The results showed that C. spinosus had become one of the dominant fish species in the fish community and mainly distributed in the north of 35°N in Haizhou Bay. Leptochela gracilis, Metapenaeopsis dalei, and Latreutes planirostris were the most important prey species for C. spinosus. Feeding hotspot analysis showed that the feeding hotspots of C. spinosus were mainly distributed around the 30 m isobath in Haizhou Bay but did not show clear variation between years. According to the similarity in the dietary composition of C. spinosus at each station, the surveyed area was divided into two areas, i.e., an inshore area and offshore area. The body length and body weight of C. spinosus in the inshore area were significantly lower than those in the offshore area (P < 0.05). Feeding habit analysis showed that L. gracilis and L. planirostris were the primary prey species for C. spinosus among a total of 56 prey species in the inshore area. In contrast, C. spinosus mainly fed on M. dalei among 64 species present in the offshore area. The overlap index between the two areas is 0.55, which is not significant. The percentage of empty stomachs of C. spinosus in the inshore area was significantly lower than that in the offshore area (P < 0.05), and the condition index was significantly higher in the inshore area (P < 0.05). The mean stomach fullness index in the inshore area was higher than that in the offshore area, but there was no significant difference (P > 0.05). This study showed that there was obvious spatial heterogeneity in the feeding habits of C. spinosus. Therefore, we conclude that it is essential to consider spatial heterogeneity when studying the feeding ecology of fish.