Constructing the ecological security pattern of cultivated land landscape is an important measure to resist the regional ecological risk to cultivated land and ensure its ecological quality. The study takes Fengxin, a typical southern hilly county, as the research area, and selects some landscape pattern indices to construct an ecological security evaluation model for cultivated land landscapes in that area, and analyzes the ecological security status and spatial aggregation characteristics of cultivated land landscape at county scale. Then, the spatial and regional differences in the effects of natural and socio-economic factors on the regional ecological security were explored by using the geographically weighted regression model. The results showed that:Villages with a "dangerous" state of cultivated land landscape ecological security accounted for 12.92% of the total research area, and the spatial security of regional cultivated land landscape has obvious spatial clustering; Compared to the traditional global regression model, the geographically weighted regression model has better goodness of fit, can reveal the regional differences of influencing factors preferably; The influence of natural and socio-economic factors on the ecological security of cultivated land landscape has significant spatial nonstationarity. According to the regional effect differences of the influence factors, the study area could be divided into the negative impact areas of distance to residents, terrain index and annual average rainfall, and positive impact zone of population density. The study provides a reference for determining the source of ecological security disturbance to cultivated land landscape, and exploring how to implement cultivated land protection countermeasures in spatial areas.