The alpine meadow is important to animal husbandry and serves as a key ecological barrier in the alpine region. It is easily influenced by natural and human agricultural development factors; multi-period remote sensing images and statistical data were used to analyze the factors influencing the landscape of the study area. With the support of remote sensing and GIS technology, the landscape pattern index model was used to analyze the temporal-spatial characteristics of the landscape evolvement of Hezuo from 2000 to 2016. In addition, we analyzed the driving forces of important facets of landscape evolution through a Logistic regression model from a spatial perspective. The results showed that the vegetation cover area proportion was maintained at 80% during the study period, but various types of structural change in the landscape were clearly apparent. The Alpine Meadow landscape pattern changed significantly from 2000 to 2016. Other meadow areas (mainly sub-alpine and marsh meadows), dry land areas, and construction land areas presented a tendency of increase and the annual rate of change accelerated. Shrub land areas, shrub meadow areas, and water body areas showed a tendency to decrease. The annual change in landscape area increased. The annual rate of change of the alpine meadow landscape area was 1.118% from 2000 to 2009, while the rate was 2.067% from 2009 to 2016. The annual change in landscape area was approximately 0.691×10⁴ hm². While the overall area change of the five major landscape changes was not significant, the conversion of each sub-category was. At the landscape level, the change in the landscape index indicated that the landscape fragmentation was stronger from 2000 to 2009. With the optimization of landscape status, the overall trend was toward integration from 2009 to 2016. At the patch level, the type of pattern was quite different and the change was clear. Natural factors are the main constraints on the formation and structural changes of the regional landscape. Altitude and slope factors have significant effects on the landscape evolution of different grades. The vegetation coverage factor has a significant effect on grassland landscape evolution, while distance factors have significant effects on shrub meadows and the evolution of other meadows; however, they had different contributions to landscape evolution from 2000 to 2016. Human-related factors played an accelerated role in grassland ecology and driving landscape evolution. Among them, ecological protection and ecological civilization construction of the study area achieved clearly apparent results during the study period.