Natural features and ecosystem conditions at coastal zones have been changing with sea reclamation activities, intensive human exploitation, and utilization. The study area is located in a coastal reclamation area in mainland of China. Vector data for the coastal reclamation area were obtained using a human-computer interactive visual interpretation method. Based on the vector data, the impacts of coastal reclamation on changes in the landscape types and ecosystem services in the coastal reclamation area were evaluated. Important eco-zone and eco-fragile areas were identified based on the results of ecosystem service assessment. The main conclusions of this study were as follows:(1) The characteristics of the Landscape Ecological Redline in the coastal reclamation area showed a generally dispersed and regionally centralized distribution. (2) The Landscape Ecological Redline was distributed in the landscape of artificial wetland and remaining natural wetland. The sea reclamation area is important for researching the integration of land and sea. These results provide data support and methods for integrating the land and sea as a research case to improve management systems of the land and sea.