Ecosystem services can be used as an effective tool for integrating science and policy research and to address complex ecological problems (such as rapid degradation of different landscape types and ecosystem services) as a result of human disturbances. This study summarizes an trend of recent studies in the field of ecosystem services models, including the basic disciplines, the fundamental theories, the types of integrated simulation models and related limitations, which showed that the integrated modeling framework were still obscure in the field of ecosystem services and landscape patterns. Based on this review from the perspective of systems science, a conceptual framework was proposed for this field. The framework was described by three synergetic dimensions, including an interactive layer of different system elements, a model layer, and a data layer. The main results are as follows:1) the interdisciplinary knowledge feedback loop of "policy-decision process-landscape-ecosystem service-socioeconomic system" is the theoretical basis of the system elements layer in the field of integration theory; 2) the integrated simulation model is and will be the core tool in the model layer for methodology development; and 3) the integration of multi-source and long time-series data is a fundamental research to support the development and application of integrated model. The integration of ecosystem services and landscape patterns can provide scientific support for regional eco-environmental governance and also can be used to cope with the challenges of ecosystem service science and application in the future.