Dry-hot wind is one of the major meteorological hazards in Huang-Huai-Hai region, which commonly occurs at the filling stage of winter wheat and can severely influence the wheat growth and yield. There are two types of dry-hot wind in Huang-Huai-Hai region:1) high temperature with low humidity and 2) wilting heat after rain. By using daily meteorological data (daily maximum temperature, relative humidity at 14:00, wind speed at 14:00, and daily precipitation) and winter wheat growth data of 65 stations in Huang-Huai-Hai region from 1961 to 2015, the spatial-temporal characteristics of dry-hot wind in the past 55 years was analyzed. The results showed that both the dry-hot wind days and process times were higher in central-south Hebei province, north Henan province, and west and north Shandong province in Huang-Huai-Hai region; among these areas, central-south Hebei province was the most severely affected area. It was found that both the average first occurrence day and the earliest first occurrence day of dry-hot wind was gradually delayed from south to north and from inland to coast. Dry-hot wind days increased gradually with the grain filling process of winter wheat; thus, the mid and late phases of grain filling were identified as the critical resistance stages to dry-hot wind. Both the annual average days and process times of dry-hot wind showed decreasing trend from 1961 to 2015 in Huang-Huai-Hai region, especially the severe dry-hot wind days and severe process times decreased more obviously. Among of which, the decreasing trend was more obviously in southeast Hebei province, northwest Shandong province and northeast Henan province. It should be noted that extreme climate events occur frequently under the background of climate warming, and extreme dry-hot wind events may occur in some regions under certain conditions. For example, the average number of dry-hot wind days in Huang-Huai-Hai region was 8.1d in 2001, which was the maximum record from 1961 to 2015 in this region. It should be taken into account for the prevention of dry-hot wind in wheat planting.