The prevention and control of saline-alkali land is an effective way to improve the comprehensive treatment of saline-alkali land and reduce the cost of treatment for such regions. It is also an important way to ensure regional ecological restoration, sustainable land use, and food security. At present, studies on the prevention and control of saline-alkali land based on the analysis of regional landscape ecological risk are not sufficient. By considering the perspective of the theory of landscape ecology, this case study aimed to analyze the ecological flow and surface resistance in Lindian County located in Heilongjiang Province by using the minimum cumulative resistance and spatial analysis based on the remote sensing and geographic information system technology. A landscape ecology risk pattern was developed to determine the zones of prevention and control of saline-alkali land by using the ecology corridor analysis method considering the key landscape and saline-alkali land, and the core areas for the prevention and control plan of saline-alkali land were determined. The results showed that the area of saline-alkali land in Lindian was 263 km² and was characterized by higher landscape ecological risk in the west and south, whereas lower risk in the northeast, central, and southwest regions. The area proportion of the high and severe risk zones was 41.24% and was intensively distributed in the downstream region surrounding the marshes, indicating that the protection of marshes is very urgent. Two landscape and ecology corridors that were considered to be the best regions of realizing the prevention and control of saline-alkali land at the lowest cost were mainly distributed in 15 villages (towns); these regions should be considered the core of prevention and control plan in the future. Our findings based on the landscape ecological risk pattern can provide a novel strategy and method for the prevention and control of saline-alkali land at the large scale and could form a scientific basis for the prevention and control of saline-alkali land in Lindian in the future.